Preparation of antifebrin coursework

As stated hereinbefore a-isopropyl-a-(Z-N-diethylamino-l-methyl ethyl) phenyl acetonitrile, on subcutaneous administration, exhibits analgesic activity in white mice in a dose of 50 mg./kg.. In contrast hereto the isomeric u-isopropyl-a-(' -diethylamino propyl) phenyl acetonitrile which differs from the above mentioned oc-iSO- propyl-a-(Z-N-diethylamino-l-methyl ethyl) phenyl acetonitrile by having only one center of asymmetry, does notexhibit'analgesic activity on subcutaneous injection which compound also possesses two centers of asymmetry exhibits, in contrast to its isomeric 'y-amino propyl compounds, analgesic properties when subcutaneously administered to mice in a dose of 50 nag/kg.

Preparation of antifebrin coursework

preparation of antifebrin coursework

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